Systolic blood pressure level and risk of intracerebral hemorrhage.

Systolic blood pressure level and risk of intracerebral hemorrhage.

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Context: Stroke prevention guidelines suggest that larger reductions in systolic
blood pressure (SBP) are positively associated with a greater reduction in the risk
of recurrent stroke and define an SBP level of less than 120 mm Hg as normal. However,
the association of SBP maintained at such levels with risk of intracerebral hemorrhage after a recent ischemic stroke is unclear.
Objective: To assess the association of maintaining low-normal vs. high-normal SBP levels with risk of intracerebral hemorrhage.
Design, Setting, and Patients: Post hoc observational analysis of a multicenter trial involving 20,330 patients (age=50 years) with recent non-cardioembolic ischemic stroke; patients were recruited from 695 centers in 35 countries from September 2003 through July 2006 and followed up for 2.5 years (follow-up ended on February 8, 2008). Patients were categorized based on their mean SBP level: very low–normal (<120 mm Hg), low-normal (120-<130 mm Hg), high-normal (130-<140 mm Hg), high (140-<150 mm Hg), and very high (=150 mm Hg).
Main Outcome Measures: The outcome of interest will be the first recurrence of intracerebral hemorrhage.

[{ "PostingID": 1970, "Title": "BI-9.159", "Description": "PRoFESS - Prevention Regimen For Effectively Avoiding Second Strokes

Medicine: dipyridamole + acetylsalicylic acid, Condition: Stroke, Phase: 4, Clinical Study ID: 9.159, Sponsor: Boehringer Ingelheim" }]