Relationship between plasma levels of a1-Antitrypsin levels and the severity of airflow limitation

Relationship between plasma levels of a1-Antitrypsin levels and the severity of airflow limitation

None

None

Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent respiratory disease characterized by shortness of breath, cough, sputum production and frequent episodes of bronchitis, especially in winter months. COPD is also associated with other chronic diseases such as hypertension and other cardiovascular diseases.
The main cause of COPD is tobacco smoking, but not all smokers develop COPD and not all with the same degree of severity. Other factors have been implicated, such as the deficiency in one protein called a1-antitrypsin (AAT). Individuals with a deficiency of this protein have an increased risk of developing COPD at an earlier age because they lack the protective effect of AAT in the lungs.
However, the role of this protein in the development of COPD in patients not considered to have the deficiency is unknown. There have been only a few studies analysing the concentrations of this protein in healthy subjects and patients with COPD, but without the deficiency in AAT.
We think that data from the EPI SCAN study is a unique opportunity to analyse the possible role of the protein AAT as a risk factor for developing COPD in non-deficient individuals, or as a marker of disease severity, because the study collected data from a large sample of adults with and without COPD, smokers and non smokers and included blood analysis with quantification of AAT and other markers of inflammation.
We want to investigate the role of AAT in the development of COPD and identify if there are any predictors of the blood levels of this protein in adult individuals with and without COPD

[{ "PostingID": 1656, "Title": "GSK-107335", "Description": "COPD prevalence estimation in Spanish population." }]

https://www.archbronconeumol.org/en-serum-levels-alpha1-antitrypsin-their-relationship-articulo-S1579212920300100

DOI: 10.1016/j.arbres.2019.03.001