Update of individual data meta-analysis of intra-articular corticosteroids in knee and hip osteoarthritis

Update of individual data meta-analysis of intra-articular corticosteroids in knee and hip osteoarthritis

Background:Osteoarthritis (OA) is a highly prevalent and disabling condition with limited safe and effective treatment options available. Intra-articular corticosteroid injections are frequently utilised in knee or hip OA patients in the setting of unresponsiveness or intolerance to conservative treatment measures or common pharmacological agents such as non-steroidal anti-inflammatory drugs.The aim of this individual patient data meta-analysis is to investigate the efficacy of intra-articular corticosteroid injections in patients with hip and knee OA.Method and analysis:A systematic literature search will be conducted for randomised clinical trials in corticosteroid intra-articular injection with placebo for knee and hip osteoarthritis. Literature searches will be conducted through Pubmed (Medline), EMBASE, Web of Science, Cochrane Central, and SCOPUS. Individual patient data from each study will be requested and obtained from the corresponding authors of the trials. Risk of bias will be assessed using the Cochrane Collaboration's tool.The primary outcome will be pain severity at short term with secondary outcomes being pain severity at other time points

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