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Effects of tumor burden change (response) on survival in mesothelioma








Effects of tumor burden change (response) on survival in mesothelioma


Aaron Mansfield


Mayo Clinic


I am funded by the NIH and my time would be used to complete this project with that of Prof. Symanowski's.


ASCO Lung Cancer Education Committee


20 March 2018


Overall survival is the gold standard of end-points for clinical trials in oncology; however, this measurement is complicated by competing mortality and cross-over to other therapies. Responses, or reductions in tumor burden, are commonly analyzed in clinical trials, but nobody has demonstrated whether response rates correlate with survival outcomes in mesothelioma. Demonstration of the correlation of responses with survival outcomes would provide validation to using response rates as endpoints in this disease.




Statistical Analysis Plan


The publication citation will be added after the research is published.