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Does Shingrix vaccination reduces the risk of stroke?








Does Shingrix vaccination reduces the risk of stroke?


Benson Ogunjimi


University of Antwerp & Antwerp University Hospital






03 January 2019


BackgroundVaricella-zoster virus (VZV) causes chickenpox, mainly during childhood, and remains afterwards in a sleeping state in the body. After awakening of the virus, VZV can cause a painful and debilitating disease called shingles. It has been known for some time that the risk of stroke in children is higher during the first six months following chickenpox. Moreover, several recent studies have also found an association between stroke and shingles.GSK has been developing a potent vaccine (Shingrix) against shingles.ObjectivesIn this study, we aim to assess whether the use of the Shingrix might not only reduce the risk of shingles, but potentially also the risk of stroke.



[{ "PostingID": 14523, "Title": "GSK-110390", "Description": "Efficacy, safety, and immunogenicity study of GSK Biologicals' Herpes Zoster vaccine GSK1437173A in adults aged 50 years or older" },{ "PostingID": 14524, "Title": "GSK-113077", "Description": "Efficacy, safety and immunogenicity study of GSK Biologicals' Herpes Zoster vaccine GSK1437173A in adults aged 70 years or older" }]

Statistical Analysis Plan